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This Article Figures Only Full Text Full Text (PDF) Supplemental Data All Versions of this Article: AJPH.2008.147223v1 100/2/341    most recent Submit a response View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Apelberg, B. J. Articles by Samet, J. M. PubMed PubMed Citation Articles by Apelberg, B. J. Articles by Samet, J. M. Related Collections Epidemiology Mortality Other Tobacco Smoking Cessation Tobacco Control

Benjamin J. Apelberg, PhD, MHS, Georgiana Onicescu, ScM, Erika Avila-Tang, PhD, MHS and Jonathan M. Samet, MD, MS

At the time of the study, Benjamin J. Apelberg, Georgiana Onicescu, Erika Avila-Tang, and Jonathan M. Samet were with the Institute for Global Tobacco Control, Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD.

Correspondence: Correspondence should be sent to Benjamin J. Apelberg, Institute for Global Tobacco Control, Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, 21205 (e-mail: bapelber{at}jhsph.edu). Reprints can be ordered at http://www.ajph.org by clicking on the "Reprints/Eprints" link.

Objectives. To compare potential population-wide benefits and risks, we examined the potential impact of increased nicotine replacement therapy (NRT) use for smoking cessation on future US mortality.

Methods. We developed a simulation model incorporating a Monte Carlo uncertainty analysis, with data from the 2005 National Health Interview Survey and Cancer Prevention Study II. We estimated the number of avoided premature deaths from smoking attributable to increased NRT use, before and after incorporating assumptions about NRT harm.

Results. We estimate that a gradual increase in the proportion of NRT-aided quit attempts to 100% by 2025 would lead to 40 000 (95% credible interval = 31 000, 50 000) premature deaths avoided over a 20-year period. Most avoided deaths would be attributable to lung cancer and cardiovascular disease. After we incorporated assumptions about potential risk from long-term NRT, the estimate of avoided premature deaths from all causes declined to 32 000.

Conclusions. Even after we assumed some harm from long-term NRT use, the benefits from increased cessation success far outweigh the risks. However, the projected reduction in premature mortality still reflects a small portion of the tobacco-related deaths expected over a 20-year period.