The Diagnostic Interview Schedule was employed to ascertainthe prevalence of major depressive disorder (MDD), alcohol andsubstance abuse in a sample of 424 college students aged 16to 19 years. Applying DSM III criteria, the prevalence of MDDwas 6.8 per cent; of alcohol abuse, 8.2 per cent; and of substanceabuse 9.4 per cent. Alcohol abuse was associated with MDD, butnot with other psychiatric diagnoses. Substance abuse was associatedboth with MDD and with other psychiatric diagnoses as well.The onset of MDD almost always preceded alcohol or substanceabuse suggesting the possibility of self-medication as a factorin the development of alcohol or substance abuse.
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