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Kenneth Olden, PhD, Janet Guthrie, MPA and Sheila Newton, PhD

Kenneth Olden is with the National Institute of Environmental Health Sciences and the National Toxicology Program, Research Triangle Park, NC. Janet Guthrie and Sheila Newton are with the Office of Policy, Planning and Evaluation, National Institute of Environmental Health Sciences.

Correspondence: Requests for reprints should be sent to Kenneth Olden, PhD, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709 (e-mail: olden{at}niehs.nih.gov).

The biotechnology revolution has opened new opportunities for addressing current inadequacies in decision making regarding environmental health. Strategic investments need to be made (1) to develop high-throughput technologies that could accelerate toxicity testing and generate a mechanistic understanding of toxicity, (2) to incorporate individual susceptibility into risk assessments, and (3) to establish a rational basis for testing and regulatory decision making. New initiatives of the National Institute of Environmental Health Sciences, including the Environmental Genome Project and the Toxicogenomics Center, are discussed.

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