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July 2004, Vol 94, No. 7 | American Journal of Public Health 1085-1089
© 2004 American Public Health Association

COMMENTARY

HIV Topical Microbicides: Steer the Ship or Run Aground

Michael Gross, PhD

Michael Gross is an independent consultant, Long Beach, Calif.

Correspondence: Requests for reprints should be sent to Michael Gross, 315 W 3rd St #712, Long Beach, CA 90802 (e-mail: m144{at}earthlink.net).

Six HIV candidate microbicides are scheduled to enter 6 large-scale effectiveness trials in the next year. The selection of products for testing and the design of this group of trials should be reconsidered to provide an answer to a key question now before the field: Does a sulfonated polyanion, delivered intravaginally as a gel, block HIV attachment to target cells with sufficient potency to protect women from sexually acquired HIV infection?

Paradoxically, entering more candidates into more trials may confuse or compromise efforts to identify an effective product. Instead, a single trial of the most promising product(s) best serves the current candidates while also preserving resources needed to promptly advance innovative new protective concepts into future large-scale trials.


Related articles in AJPH:

HIV and Women: When Words Speak Louder Than Actions
Michael Gross
AJPH 2004 94: 1079-1080. [Extract] [Full Text]  



This article has been cited by other articles:


Home page
 AJPHHome page
A. B. Stone
HIV TOPICAL MICROBICIDES: THE CURRENT DEVELOPMENT STRATEGY IS FULLY JUSTIFIED
Am J Public Health, November 1, 2004; 94(11): 1845 - 1846.
[Full Text] [PDF]

eLetters:

Read all eLetters

HIV topical microbicides: the current development strategy is fully justified
Alan B Stone
AJPH Online, 13 Aug 2004 [Full text]
Gross responds
Michael Gross
AJPH Online, 14 Aug 2004 [Full text]

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