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AJPH First Look, published online ahead of print Apr 26, 2005
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May 2005, Vol 95, No. 5 | American Journal of Public Health 790-799
© 2005 American Public Health Association
DOI: 10.2105/AJPH.2004.040790

PUBLIC HEALTH THEN AND NOW

Passive Immunization Against Poliomyelitis: The Hammon Gamma Globulin Field Trials, 1951–1953

Charles R. Rinaldo, Jr, PhD

Charles R. Rinaldo Jr is with the Departments of Infectious Diseases and Microbiology and Pathology, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pa.

Correspondence: Requests for reprints should be sent to Charles R. Rinaldo Jr, PhD, Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, A427 Crabtree Hall, 130 DeSoto St, Pittsburgh, PA 15261 (e-mail: rinaldo{at}pitt.edu).

Poliomyelitis has gone from being one of the worst scourges of the 20th century to nearing eradication in the 21st. This success is well known to be attributable to the Salk inactivated and Sabin attenuated poliovirus vaccines.

However, before introduction of these vaccines, William McDowall Hammon of the University of Pittsburgh Graduate School of Public Health led the first major breakthrough in prevention of the disease by using passive immunization in one of the earliest double-blind, placebo-controlled clinical trials. This study provided the first evidence that antibodies to poliovirus could prevent the disease in humans.




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Correction to "Passive Immunization Against Poliomyelitis"
Vincent R Racaniello
AJPH Online, 16 May 2005 [Full text]

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