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AJPH First Look, published online ahead of print Jul 27, 2006
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September 2006, Vol 96, No. 9 | American Journal of Public Health 1554-1559
© 2006 American Public Health Association
DOI: 10.2105/AJPH.2005.074583

HEALTH POLICY AND ETHICS

Assembling a Global Vaccine Development Pipeline for Infectious Diseases in the Developing World

Irina Serdobova, MBA, PhD and Marie-Paule Kieny, PhD

Irina Serdobova is with Axensus, Ltd, consultants, Cheltenham, Gloucestershire. Marie-Paule Kieny is with the Initiative for Vaccine Research, World Health Organization, Geneva, Switzerland.

Correspondence: Requests for reprints should be sent to Marie-Paule Kieny, PhD, Initiative for Vaccine Research, World Health Organization, Ave Appia 20, CH1211-Geneva 27, Switzerland (e-mail: kienym{at}who.int).

Commercial realities have drastically reduced private investment in the development of new public health tools, but increased awareness of this situation has resulted in the emergence of a variety of research-based, nonprofit organizations. We reviewed current vaccine developments and developed a framework for efficient research and development investments in this area.

We have identified several key "push" and "pull" forces within the vaccine research and product development environment and have examined their impacts on the process. These forces affect the global vaccine pipeline, which is composed of all individual vaccine initiatives and global partnerships (i.e., stakeholders), All of these research and development stakeholders must work together to establish and promote a global, sustainable research and development pipeline that delivers optimal vaccines and immunization technologies.






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Copyright © 2006 by the American Public Health Association