© 2008 American Public Health Association DOI: 10.2105/AJPH.2008.140376
Correspondence: Correspondence should be sent to Jeffrey P. Baker, MD, PhD, Trent Center for Bioethics, Humanities, and History of Medicine, Duke University School of Medicine, Box 3675 (DUMC), Durham, NC 27710 (e-mail: baker009@mc.duke.edu).
I appreciate Silbergelds balanced and thoughtful remarks. It is true that as early as the 1940s, thimerosal was recognized to cause topical hypersensitivity as measured by skin tests. The US Food and Drug Administration cited these concerns in its proposed rules on preservatives in skin tests and over-the-counter topical products in 1978 and 1982, as did some European countries that restricted thimerosal in the 1990s.1,2 The clinical significance of this phenomenon, however, was related to contact dermatitis rather than neurotoxicity, the focus of my article and of the vaccine and autism debate.
Although more recent studies have shown that methylmercury
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