HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text (PDF) Submit a response View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by Blizzard, L. Articles by Cochrane, J. A. Search for Related Content PubMed PubMed Citation Articles by Blizzard, L. Articles by Cochrane, J. A. Related Collections Other Maternal and Infant Health Other Respiratory Health Secondhand Smoke

Leigh Blizzard, PhD, Anne-Louise Ponsonby, PhD, Terence Dwyer, MD, Alison Venn, PhD and Jennifer A. Cochrane, BA

The authors are with the Menzies Centre for Population Health Research, University of Tasmania, Hobart. Anne-Louise Ponsonby is also with the National Centre for Epidemiology and Public Health, Australian National University, Canberra, Australian Capital Territory.

Correspondence: Requests for reprints should be sent to Leigh Blizzard, PhD, Menzies Centre for Population Health Research, University of Tasmania, Private Bag 23, Hobart 7001, Australia (e-mail: leigh.blizzard{at}utas.edu.au).

	ABSTRACT

TOP ABSTRACT INTRODUCTION METHODS RESULTS DISCUSSION References

 

Objectives. We sought to quantify the effect of good smoking hygiene on infant risk of respiratory tract infection in the first 12 months of life.

Methods. A cohort of 4486 infants in Tasmania, Australia, was followed from birth to 12 months of age for hospitalization with respiratory infection. Case ascertainment was 98.2%.

Results. Relative to the infants of mothers who smoked postpartum but never in the same room with their infants, risk of hospitalization was 56% (95% confidence interval [CI] = 13%, 119%) higher if the mother smoked in the same room with the infant, 73% (95% CI = 18%, 157%) higher if the mother smoked when holding the infant, and 95% (95% CI = 28%, 298%) higher if the mother smoked while feeding the infant.

Conclusions. Parents who smoke should not smoke with their infants present in the same room.

	INTRODUCTION

TOP ABSTRACT INTRODUCTION METHODS RESULTS DISCUSSION References

 
Postnatal exposure of infants to cigarette smoke is causally associated with an increased risk of lower respiratory tract infections such as bronchitis and pneumonia, increased prevalence of fluid in the middle ear, symptoms of upper respiratory tract irritation, and a small but significant reduction in lung function.¹ This exposure also has been linked with new cases of childhood asthma and with additional episodes and increased severity of symptoms in asthmatic children.^1,2

Medical authorities therefore recommend that parents provide a smoke-free environment for infants and children. The Committee on Substance Abuse of the American Academy of Pediatrics advocates that caregivers ask parents about tobacco use and smoke exposure at each consultation from the first prenatal visit onward. Parents who smoke should be offered assistance to stop smoking. Those parents who cannot quit should be encouraged to smoke outside the home.³

Earlier studies have suggested that the physical distance between the new baby and the smoking parent correlates with the amount of cotinine in the baby’s urine,^3,4 that urinary cotinine concentrations are lower when parents refrain from smoking in the same room with the baby,^5–7 and that lower urinary cotinine is associated with reduced risk of respiratory infection in some^8–11 though not all¹² studies of infants. The protective contribution of not smoking in the vicinity of the infant has not been fully evaluated for respiratory tract infection, however.

We undertook the first investigation of whether parents who smoke can nevertheless reduce the increased risk of respiratory infection for their infants by exercising good "smoking hygiene" (i.e., never smoking in the same room with the infant or while holding or feeding the infant). We report the results of a 12-month follow-up on a cohort of 4486 infants conducted with extensive standardized information on parental smoking and near-complete ascertainment of infants hospitalized with respiratory infection in the first 12 months of life.

	METHODS

TOP ABSTRACT INTRODUCTION METHODS RESULTS DISCUSSION References

 
The Cohort Study
The cohort came from the Tasmanian Infant Health Survey (TIHS), conducted from 1988 to 1995 to investigate the etiology of sudden infant death syndrome (SIDS) and other causes of infant mortality and morbidity in Tasmania.¹³ Eligibility of singleton infants for inclusion in the TIHS was assessed using a scoring system to identify those at highest risk of SIDS.¹⁴ (Infants from multiple births also were eligible for inclusion but ultimately were excluded from the group in this report; see "Participants and Selection Procedures.") Higher weighting was given for young maternal age, low birthweight (< 2500 g), autumn or winter month of birth, male sex, a short duration of second stage of labor, and intention to bottle-feed rather than to breastfeed.¹⁴ The sample of eligible infants represented approximately one-fifth of live births in the state of Tasmania. Infants were excluded if they had severe neonatal disease or major congenital anomalies, if they were intended for adoption, or if they were nonresidents of the main island of Tasmania. From January 1, 1988, to December 31, 1995, 11 070 live-born infants in Tasmania were eligible for inclusion in the survey.

We obtained data on 3 occasions, during the 1st, 5th, and 11th weeks postpartum. The first interview, which was conducted in the hospital, was delayed until 40 weeks postconceptional age for premature infants (those of gestation less than 37 weeks). During this interview we collected information on prenatal smoking, including the number of cigarettes smoked daily by the mother during each trimester of pregnancy and her exposure to smoking by others. The second interview was conducted at a home visit at a median postnatal age of 33 days (interquartile range: 30–40 days). During this interview we collected information on postnatal smoking, including the number of cigarettes smoked daily by the mother and information on smoking hygiene (whether the mother smoked in the same room with the infant or while holding or feeding the infant). We also gathered the same information for other smokers in the household. The third interview was conducted by telephone at a median postnatal age of 80 days (interquartile range: 73–93 days). We asked no further questions on maternal smoking but did ask mothers about illnesses the infant had suffered, including colds, tonsillitis, and chest infections. The families consented to the data being used to investigate infant morbidity and mortality during the first year of life. We obtained ethical approval from the ethics committee of the University of Tasmania, Hobart.

Validation of Measurements of Smoking Hygiene
The results of a study⁷ conducted using urinary cotinine analysis^15,16 in a sample of 100 infants from the TIHS cohort suggest that the maternal reports of smoking hygiene can be relied upon. The cotinine analyses were conducted at the National Poisons Unit, New Cross Hospital, London, England, by gas–liquid chromatography with levels as low as 0.1 ng/mL detectable.⁷ Mean urinary cotinine was 4.69 (95% confidence interval [CI] = 1.88, 11.72) times higher for infants of mothers who reported they smoked (n = 53) than it was for infants of mothers who reported they did not smoke (n = 47). Among the infants of mothers who smoked, mean urinary cotinine was 2.18 (95% CI = 1.04, 4.60) times higher for infants whose mothers reported they sometimes or always smoked in the same room with the baby (n = 32) than for infants whose mothers reported they never smoked in the same room with the baby (n = 21). These results are adjusted for breastfeeding (a source of ingested cotinine), for the number of cigarettes smoked per day by the mother, and for whether other household residents were smokers. Smoking hygiene has been related similarly to infant cotinine levels in a smaller sample from this cohort using a less sensitive assay,¹⁷ and also in a study in another population.⁵

Participants and Selection Procedures
The participants for this report were limited to TIHS infants born in the defined geographical region of southern Tasmania. There were 5817 eligible live births in this region during 1988 to 1995, of which 95.4% (n = 5552) participated in the hospital interview and 88.3% (n = 5134) participated in both the hospital and home interviews. In view of the high proportion (12%) of infants from multiple births in the cohort, the study was limited to the 4486 singletons to increase the generality of results. In the sample of singletons, 21.7% (n = 975) were born to teenage mothers, 32.6% (n = 1463) were born in March or April (autumn in Tasmania and the birth months given the greatest weighting in the selection criteria for inclusion in the TIHS cohort), 27.9% (n = 1244) were born after a 5- to 14-minute second stage of labor, 70% (n = 3138) were boys, 22% (n = 986) were of low birthweight, and 45.2% (n = 2027) were not being breastfed at the time of home interview.

Definition of Respiratory Infection
The respiratory infection category included upper respiratory tract infections (International Classification of Diseases, Ninth Revision, Clinical Modification¹⁸ (ICD-9-CM): 460, 462–465, 474); lower respiratory tract infections, including pneumonia (ICD-9-CM: 480–482, 485, 486), bronchitis and bronchiolitis (ICD-9-CM: 466, 490), and pleurisy (ICD-9-CM: 511); and influenza with other respiratory manifestations (ICD-9-CM: 487.1). We found no cases of several other possible types of respiratory infection (ICD-9-CM: 472, 475, 476, 478.21, 478.22, 478.24, 478.29, 478.71, 478.9, 483, 484, 487.0, 491, 494, 510).

Hospital Admission for Respiratory Infection
In southern Tasmania, most pediatric cases with a medical or emergency problem requiring hospitalization are admitted to the Royal Hobart Hospital, a large government-funded teaching hospital. For the period 1988 to 1996, the hospital provided us with paper summaries of discharge diagnoses for pediatric patients aged 12 months or younger when admitted. Those records included 1430 infants diagnosed with a respiratory infection. Using a record linkage method previously employed in a study of infant apnea/cyanosis,¹⁹ we identified 416 infants that were in our study sample. Although 22% (n = 90) had repeat admissions, each infant was counted only once as an incident case. The 416 infants included 386 singletons.

There are 3 other hospitals in southern Tasmania, each privately owned. One of those hospitals did not admit any pediatric patients during 1988 to 1996. Another did not admit any infants from our sample. The third hospital admitted pediatric patients, but we did not have access to identifying information. Based on a review of the admission records of this hospital for the 2-year period March 1995 to February 1997 and the percentage of mothers in our sample (27.4%) and in southern Tasmania²⁰ with private health insurance, we estimate that around 7 of the 77 pediatric patients admitted by this hospital during 1988 to 1996 were infants from our sample. Not having information for these infants reduced case ascertainment by only 1.8% (n = 7).

Data Analysis
We calculated risk of respiratory infection as the proportion of infants hospitalized for respiratory tract infection during the first 12 months of life. To obtain adjusted estimates of ratios of risk and of prevalence, we used log binomial regression^21,22 with binary (0/1) predictors for categories of the study factor other than a reference category. We obtained 95% confidence limits from the likelihood ratio-based confidence limits. We used a single linear predictor for tests of trend. We adjusted in analysis for all cohort selection factors but replaced mothers’ intention to breastfeed at time of birth with actual failure to breastfeed after 24 days. We also dropped maternal age from the regression model to estimate the effect of birth order, with which it was correlated (r = 0.424). We assessed statistical interaction from the coefficient and standard error of a product term. A probability of type I error of 5% was regarded as sufficiently small. We made no adjustment for multiple testing but report²³ all analyses undertaken to allow readers to make formal adjustments if they desire.

To examine the sensitivity of our results to the nonascertainment of 7 cases, we reestimated the relative risk (RR) of respiratory infection for maternal smoking after reclassifying as diseased (admitted to hospital with a respiratory infection) 7 infants chosen at random from among the nondiseased infants of mothers with private health insurance. The measure of maternal smoking was smoking hygiene (mother not a smoker, mother never smokes in the same room with the baby, mother sometimes/always smokes in the same room with the baby). We report results for 3 distributions of reclassified infants. These were good smoking hygiene (0–7–0) at one extreme, poor smoking hygiene (0–0–7) at the other, and an intermediate distribution (6–1–2) of 9 diseased infants that quite closely matched the actual distribution (43–7–14) among diseased infants of mothers with private health insurance. We performed this procedure 10 000 times for each distribution and report mean values of the RR estimates and of the 95% confidence limits.

	RESULTS

TOP ABSTRACT INTRODUCTION METHODS RESULTS DISCUSSION References

 
Risk of Respiratory Infection
In this cohort of singleton infants, 7.8% were hospitalized for a respiratory tract infection during the first 12 months of life.

Infant, Maternal, and Family Factors Associated With Risk
Risks and adjusted RR of respiratory infection requiring hospitalization are shown in Table 1. The adjustment factors include younger maternal age (linear trend P = .010), lower birthweight (trend P < .001), male sex (RR = 1.29 [95% CI = 1.03, 1.62]), March–April (RR = 1.29 [95% CI = 0.99, 1.66]) or May–July (RR = 1.30 [95% CI = 1.02, 1.67]) month of birth, and duration of breastfeeding. Other significant predictors were maternal education and birth order.

Smoking in the Same Room With the Baby
Of the mothers who smoked, 71.8% reported that they sometimes or usually smoked in the same room with the baby. This type of poor maternal smoking hygiene was more frequent among younger mothers (trend P = .004) and mothers who smoked more cigarettes daily. Other factors associated with poor smoking hygiene are shown in Table 2.

Prenatal vs Postnatal Smoking
Of the mothers who smoked in the postnatal period, 97.0% also had smoked during pregnancy. Prenatal smoking in each trimester of pregnancy was associated with higher risk of respiratory infection among the infants, with the strongest dose response for smoking in the third trimester (Table 1). Just as had been the case when the effect of postnatal daily cigarettes was adjusted for postnatal smoking hygiene, the number of cigarettes smoked daily by the mother during the third trimester was no longer a significant predictor (trend P = .824) after adjustment for smoking hygiene.

To further examine this issue, we identified all 65 mothers who had smoked in the postnatal period but not during pregnancy. The risk (10.7%) of respiratory infection for their infants was greater than the risk (6.0%) for infants of mothers who did not smoke at either time. Adjusted for the cohort selection factors, the RR estimate for this postnatal-only smoking was 1.58 (95% CI = 0.69, 3.00). Adjusting also for the number of other smokers in the household (RR = 1.51 [95% CI = 0.66, 2.89]) or maternal education (RR = 1.57 [95% CI = 0.69, 2.98]) resulted in only minor changes.

Sensitivity of Results to Incomplete Ascertainment
Around 7 infants in this sample may have been admitted with respiratory infection to a fee-charging private hospital. The adjusted RR estimates for poor smoking hygiene would have been 1.36 (95% CI = 1.00, 1.87) if each mother smoked but never in the same room with the baby and 1.63 (95% CI = 1.18, 2.29) if each mother smoked in the same room with the baby. Those are the extreme possibilities; if most of the 7 mothers were nonsmokers, as expected from the actual proportion of smokers among mothers with health insurance, the revised estimate would have been almost unchanged at RR = 1.55 (95% CI = 1.13, 2.17). Alternatively, restricting the analyses to the infants of mothers without private health insurance also produced an elevated RR estimate for poor smoking hygiene (RR = 1.46 [95% CI = 1.04, 2.11]).

Smoking When Holding or Feeding the Infant
Of postnatal smokers, 27.0% reported smoking when holding the infant, and 17.5% reported smoking when feeding the infant. The RR estimates for these more proximal types of poor smoking hygiene showed even greater elevation in risk (Table 3).

Smoking Hygiene and Respiratory Infection Reported by Mothers
We examined parental reports of respiratory infection to determine whether poor smoking hygiene also was associated with elevated risk of infections not requiring hospitalization. The parents had reported in the telephone interview during the 11th postnatal week whether their infants had suffered colds, tonsillitis, or chest infections. Those reports had predictive validity because subsequent hospitalization with respiratory infection was 5.78 (95% CI = 3.16, 11.85) times more likely for infants with at least 1 reported episode than for infants with no reported episode. Elevated risk of respiratory infection for poor smoking hygiene was not limited to infants admitted to the hospital; poor smoking hygiene at 1 month was significantly associated with reported respiratory infection for infants who had not been hospitalized in the first 10 weeks (Table 4).

	DISCUSSION

TOP ABSTRACT INTRODUCTION METHODS RESULTS DISCUSSION References

If these associations are causal, mothers who find it difficult to give up smoking can at least reduce the susceptibility of their infants to serious respiratory infection. Exercising good smoking hygiene—not smoking in the same room with the baby—eliminated more than 70% of the excess risk of hospitalization with respiratory infection associated with maternal postnatal smoking.

One of the strengths of this study is that information was collected in a standardized way over time. Selection bias due to nonresponse²⁴ is unlikely to be a major problem because of the high response rates. Nearly all hospital admissions for respiratory infection were ascertained, and the small number of cases not ascertained did not unduly influence the results. Although there is potential for admission rate bias²⁴ if some infants were admitted to the hospital by clinicians to provide respite from unfavorable home environments, we found that poor smoking hygiene also increased the risk of parent-reported colds, tonsillitis, and chest infections for nonhospitalized infants. Parental reports of those infections were strongly associated with hospitalization with respiratory infection in the full sample, indicating that these reports had validity and further suggesting that the differences in risk due to smoking hygiene are real.

Although the smoking data are based on self-report, reporting bias is an unlikely explanation of these findings. The results of a validation study⁷ conducted using urinary cotinine analysis in a sample of 100 infants from the cohort suggest that the maternal reports of smoking hygiene are reliable.⁷ In addition, an examination of the cluster of maternal factors associated with the reports of smoking hygiene revealed some evidence of construct validity for the hygiene data. The mothers with good smoking hygiene at 4 weeks of infant age were generally older, breastfeeding, and better educated. They smoked fewer cigarettes per day and less often lived with other smokers; the smokers they did live with more often also practiced good hygiene. These mothers more often lived in households with more rooms per smoker, plausibly offering more opportunity to provide a smoke-free area for the infant. Furthermore, adding to the confidence that can be placed in these results, respiratory outcomes have been directly related to higher (later) birth order,^25,26 parental smoking,^27,28 male sex,²⁹ and short duration of breastfeeding³⁰ in previous studies.

This cohort comprised one-fifth of live births in the defined geographical area, but weighting in selection of individual infants was given to risk factors for SIDS. The cohort is not representative of the general infant population of Australia, but it does not need to be for inferences about disease causation to be valid.^23,31 What matters in a study to test causal hypotheses is that the sample contains a wide distribution of the study factor and its effect modifiers.³¹ A particular advantage of this study base, given that maternal postnatal smoking was the principal study factor, was the high proportion of mothers who smoked. The confounding effects of the maternal and infant factors used in selection were always taken into account in the multivariate analyses.

Consistent with previous findings for this cohort,¹⁷ poor postnatal smoking hygiene was associated with prenatal smoking. We cannot discount the possibility that the higher risk of respiratory infection for infants of mothers with poor smoking hygiene was due in part to exposure in utero, but our results and other findings suggest that postnatal smoking hygiene itself presents a relevant exposure. In this study, adjusting for prenatal smoking did not diminish the estimated effect of poor postnatal smoking hygiene. Furthermore, postnatal-only exposure was associated with an elevation in risk similar to postnatal-plus-prenatal exposure, and in households of mothers who did not smoke, smoking by others was associated with increased risk in a dose–response fashion. There have been similar findings in other studies of nonsmoking mothers.²⁷

In conclusion, the risk of respiratory tract infection requiring hospitalization in the first year of life for the infants of mothers who smoked in the postnatal period was least for those whose mothers did not smoke in the same room with them. Not smoking at all is the safest option, but mothers who find it difficult not to smoke postpartum can at least reduce 1 of the deleterious effects of their smoking on the respiratory health of their infants. This first report of a protective effect of good smoking hygiene on respiratory tract infection provides quantitative evidence to support the current recommendations³ that infants should not be exposed to tobacco smoke.

	Acknowledgments

 
This study was funded in part by a research grant awarded by the Royal Hobart Hospital.

We thank the hospital for making available its records of pediatric admissions.

Human Participant Protection

The ethics committee of the University of Tasmania approved this project.

	Footnotes

 
L. Blizzard contributed to planning this study, undertook the data analysis, and drafted the manuscript. A.-L. Ponsonby contributed to planning the main cohort study, and devised and planned this study. T. Dwyer devised and planned the main cohort study. J. A. Cochrane undertook the data linkage. All authors participated in data interpretation and in revising the manuscript.

Peer Reviewed

Accepted for publication July 1, 2002.

	References

TOP ABSTRACT INTRODUCTION METHODS RESULTS DISCUSSION References

 
1. Jinot J, Bayard S. Respiratory health effects of passive smoking: EPA’s weight-of-evidence analysis. J Clin Epidemiol. 1994;47:339–349.[Web of Science][Medline]

2. Charlton A. Children and passive smoking: a review. J Fam Pract. 1994;38:267–277.[Web of Science][Medline]

3. American Academy of Pediatrics Committee on Substance Abuse. Tobacco’s toll: implications for the pediatrician. Pediatrics. 2001;107:794–798.[Abstract/Free Full Text]

4. Matsuki H, Kasuga H, Osaka F, Yanagisawa Y, Nishimura H. A comparative study on the health effects of smoking and indoor air pollution in summer and winter. Tokai J Exp Clin Med. 1985;10:427–437.[Medline]

5. Woodward A, Grgurinovich N, Ryan P. Breast feeding and smoking hygiene: major influences on cotinine in urine of smokers’ infants. J Epidemiol Community Health. 1986;40:309–315.[Abstract/Free Full Text]

6. Irvine L, Crombie IK, Clark RA, et al. What determines the level of passive smoking in children with asthma? Thorax. 1997;52:766–769.[Abstract]

7. Dwyer T, Ponsonby AL, Couper D. Tobacco smoke exposure at one month of age and subsequent risk of SIDS—a prospective cohort study. Am J Epidemiol. 1999;149:593–602.[Abstract/Free Full Text]

8. Reese A, James I, Landau L, Lesouef P. Relationship between urinary cotinine level and diagnosis in children admitted to hospital. Am Rev Respir Dis. 1992;146:66–70.[Web of Science][Medline]

9. Bakoula CG, Kafritsa YJ, Kavadias GD, et al. Objective passive-smoking indicators and respiratory morbidity in young children. Lancet. 1995;346:280–281.[Web of Science][Medline]

10. Rylander E, Pershagen G, Eriksson M, Bermann G. Parental smoking, urinary cotinine, and wheezing bronchitis in children. Epidemiology. 1995;6:289–293.[Web of Science][Medline]

11. Gurkan F, Kiral A, Dagli E, Karakoc F. The effect of passive smoking on the development of respiratory syncytial virus bronchiolitis. Eur J Epidemiol. 2000;16:465–468.[Web of Science][Medline]

12. Margolis PA, Keyes LL, Greenberg RA, Bauman KE, LaVange LM. Urinary cotinine and parent history (questionnaire) as indicators of passive smoking and predictors of lower respiratory illness in infants. Pediatr Pulmonol. 1997;23:417–423.[Web of Science][Medline]

13. Dwyer T, Ponsonby AL, Newman NM, Gibbons LE. Prospective cohort study of prone sleeping position and sudden infant death syndrome. Lancet. 1991;337:1244–1247.[Web of Science][Medline]

14. D’Espaignet ET, Dwyer T, Newman NM, Ponsonby AL, Candy S. The development of a model for predicting infants at high risk of sudden infant death syndrome in Tasmania. J Paediatr Perinatal Epidemiol. 1990;4:422–435.

15. Greenberg RA, Haley NJ, Etzel RA, Loda FA. Measuring the exposure of infants to tobacco smoke. N Engl J Med. 1984;310:1075–1078.[Abstract]

16. Feyerabend C, Russell MAH. A rapid gas-liquid chromatographic method for the determination of cotinine and nicotine in biological fluids. J Pharm Pharmacol. 1990;42:450–452.[Web of Science][Medline]

17. Ponsonby AL, Couper D, Dwyer T. Features of infant exposure to tobacco smoke in a cohort study in Tasmania. J Epidemiol Community Heath. 1996;50:40–46.[Abstract/Free Full Text]

18. International Classification of Diseases, Ninth Revision, Clinical Modification. Hyattsville, Md: National Center for Health Statistics; 1980. DHHS publication PHS 80-1260.

19. Ponsonby AL, Dwyer T, Couper D. Sleeping position, infant apnea and cyanosis: a population-based study. Pediatrics. 1997;99:1–7.[Abstract/Free Full Text]

20. Kilmartin MR, Woodward DR, Blizzard CL, Turner K. Immunisation of babies: the mother’s perspective. Aust Fam Physician. 1998;27(suppl):S11–S4.

21. Wacholder S. Binomial regression in GLIM: estimating risk ratios and risk differences. Am J Epidemiol. 1986;123:174–184.[Abstract/Free Full Text]

22. Skov T, Deddens J, Petersen MR, Endahl L. Prevalence proportion ratios: estimation and hypothesis testing. Int J Epidemiol. 1998;27:91–95.[Abstract/Free Full Text]

23. Rothman KJ. Modern Epidemiology. Boston, Mass: Little, Brown and Co., 1986:150.

24. Sackett DL. Bias in analytic research. J Chronic Dis. 1979;32:51–63.[Web of Science][Medline]

25. Leeder SR, Corkhill R, Irwig LM, Holland WW, Colley JRT. Influences of family factors on the incidence of lower respiratory illness during the first year of life. Brit J Prev Soc Med. 1976;30:203–212.

26. Strachan DP, Taylor EM, Carpenter RG. Family structure, neonatal infection, and hay fever in adolescence. Arch Dis Child. 1996;74:422–426.[Abstract/Free Full Text]

27. Strachan DP, Cook DG. Parental smoking and lower respiratory illness in infancy and early childhood. Thorax. 1997;52:905–914.[Abstract]

28. Li JSM, Peat JK, Xuan W, Berry G. Meta-analysis on the association between environmental tobacco smoke (ETS) exposure and the prevalence of lower respiratory tract infection in early childhood. Pediatr Pulmonol. 1999;27:5–13.[Web of Science][Medline]

29. Kelsey MC, Mitchell CA, Griffin M, Spencer RC, Emmerson AM. Prevalence of lower respiratory tract infections in hospitalised patients in the United Kingdom and Eire—results from the Second National Prevalence Survey. J Hosp Infect. 2000;46:12–22.[Web of Science][Medline]

30. Nafstad P, Jaakkola JJ, Hagen JA, Botten G, Kongerud J. Breastfeeding, maternal smoking and lower respiratory tract infections. Eur Respir J. 1996;9:2623–2629.[Abstract]

31. Miettenen O. Design of the study base. In: Theoretical Epidemiology: Principles of Occurrence Research in Medicine. New York, NY: John Wiley & Sons, 1985:46–68.

This article has been cited by other articles:

				M. F. Hovell, J. M. Zakarian, G. E. Matt, S. Liles, J. A. Jones, C. R. Hofstetter, S. N. Larson, and N. L. Benowitz Counseling to reduce children's secondhand smoke exposure and help parents quit smoking: A controlled trial Nicotine Tob Res, October 29, 2009; (2009) ntp148v1. [Abstract] [Full Text] [PDF]

				M K Kwok, C M Schooling, L M Ho, S S L Leung, K H Mak, S M McGhee, T H Lam, and G M Leung Early life second-hand smoke exposure and serious infectious morbidity during the first 8 years: evidence from Hong Kong's "Children of 1997" birth cohort Tob. Control, August 1, 2008; 17(4): 263 - 270. [Abstract] [Full Text] [PDF]

				A.-L. Ponsonby, N. Glasgow, A. Pezic, T. Dwyer, K. Ciszek, and M. Kljakovic A temporal decline in asthma but not eczema prevalence from 2000 to 2005 at school entry in the Australian Capital Territory with further consideration of country of birth Int. J. Epidemiol., June 1, 2008; 37(3): 559 - 569. [Abstract] [Full Text] [PDF]

				M. B. F. Stepans, S. L. Wilhelm, and K. Dolence Smoking hygiene: reducing infant exposure to tobacco. Biol Res Nurs, October 1, 2006; 8(2): 104 - 114. [Abstract] [PDF]

				M. Meates-Dennis BRONCHIOLITIS Arch. Dis. Child. Ed. Pract., December 1, 2005; 90(4): ep81 - ep86. [Full Text] [PDF]

				G. M. Leung, L.-M. Ho, and T.-H. Lam Secondhand Smoke Exposure, Smoking Hygiene, and Hospitalization in the First 18 Months of Life Arch Pediatr Adolesc Med, July 1, 2004; 158(7): 687 - 693. [Abstract] [Full Text] [PDF]

This Article Abstract Full Text (PDF) Submit a response View Shopping Cart Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by Blizzard, L. Articles by Cochrane, J. A. Search for Related Content PubMed PubMed Citation Articles by Blizzard, L. Articles by Cochrane, J. A. Related Collections Other Maternal and Infant Health Other Respiratory Health Secondhand Smoke