Mika Kivimäki ^1*, Mirka Hintsanen ², Liisa Keltikangas-Järvinen ², Marko Elovainio ², Laura Pulkki-Råback ², Jussi Vahtera ³, Jorma S. A. Viikari ⁴, Olli T. Raitakari ⁴

¹ Finnish Institute of Occupational Health and Univeristy of Helsinki
² University of Helsinki
³ Finnish Institute of Occupational Health
⁴ University of Turku

^* To whom correspondence should be addressed. E-mail: mika.kivimaki{at}ttl.fi.

	Abstract

We examined whether preemployment influences confounded the association between job strain and atherosclerosis. We assessed biological, familial, and socioeconomic risk factors at ages 12 to 18 and job strain and carotid artery intima-media thickness at ages 33 to 39 for a cohort of 358 men. Adolescent risk factors predicted adult intima-media thickness but had little effect on the dose-response relation between higher-level job strain and greater intima-media thickness. Preemployment influences did not confound the association between job strain and atherosclerosis.

Key Words: Cardiovascular Disease, Epidemiology, Social Science

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