RESEARCH AND PRACTICE:
Judith A. Cook, Dennis Grey, Jane Burke, Mardge H. Cohen, Alejandra C. Gurtman, Jean L. Richardson, Tracey E. Wilson, Mary A. Young, and Nancy A. Hessol
Depressive Symptoms and AIDS-Related Mortality Among a Multisite Cohort of HIV-Positive Women
Am J Public Health 2004; 94: 1133-1140
[Abstract][Full text][PDF]
In 1985 I first suggested low DHEA may be involved in AIDS and
depression and that cortisol may be the natural antagonist of DHEA
(copyrighted). Years later, low DHEA has been connected with depression
and AIDS and the negative effects of an increased cortisol to DHEA ratio
have been reported. I also suggested increasing morbidity and mortality
of AIDS result from further loss of DHEA.
I suggest the findings that "AIDS-related deaths were more likely
among women with chronic depressive symptoms, and symptoms were more
severe among women in the terminal phase of their illness." may result
from exaggerated loss of DHEA.